Under the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing human evidence as well as supporting evidence from animal studies. (U.S. EPA, 1979, 1985, 1998; ATSDR, 1997).
US EPA. United States Environmental Protection Agency ... Environmental Topics; Laws & Regulations; About EPA; IRIS. Contact Us; Hexachlorobutadiene CASRN 87-68-3 | DTXSID7020683 IRIS Summary (PDF ) (9 pp, 100 K) Key IRIS ... Not assessed under the IRIS Program. Cancer Assessment. Weight of Evidence for Cancer (PDF) (9 …
This IRIS assessment for Perfluorohexanesulfonic Acid (PFHxS) consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
Basis: Based on inadequate data in humans and limited evidence of carcinogenicity in animals. Male ICR and B6C3F1 mice exposed to methylmercuric chloride in the diet had an increased incidence of renal …
Basis: Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), ethylene oxide is "carcinogenic to humans" by the inhalation route of exposure, based on (1) strong, but less than conclusive on its own, epidemiological evidence of lymphohematopoietic cancers and breast cancer in EtO exposed workers, (2) extensive …
US EPA. United States Environmental Protection Agency. Search ... About EPA; IRIS. Contact Us; 1,2,4-Trimethylbenzene CASRN 95-63-6 | DTXSID6021402 Toxicological Review (PDF) (150 pp, 2.65 M) IRIS Executive Summary (PDF) (10 pp, 323 K) Supplemental Information on the IRIS Toxicological Review of Trimethylbenzene ...
Please Note: The main sources of information for this fact sheet are the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profile for Manganese (1) …
This IRIS assessment for Coke oven emissions consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Developmental, Immune: 2 x 10 -9 (Chronic) Decreased serum antibody concentrations for tetanus and diphtheria in children; …
Basis: Sufficient animal evidence. Ten rat bioassays and one mouse assay have shown statistically significant increases in renal tumors with dietary and subcutaneous exposure to several soluble lead salts.
Basis: Observation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers; This may be a synopsis of the full weight-of-evidence narrative.
Cancer Potential. The US EPA (U.S. EPA, 1993) has stated that manganese is "not classifiable as to human carcinogenicity." This conclusion was based on the …
On the basis of sufficient evidence for carcinogenicity in human epidemiology studies, VC is considered to best fit the weight-of-evidence Category "A," according to current EPA Risk Assessment Guidelines (U.S. EPA, 1986).
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Immune, Hematologic: 3 x 10 -1: Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and volunteers
In April 2019, the IRIS Program announced under the Program Outlook that in an effort to modernize its workflow, IRIS has moved away from one-size-fits-all assessments to a portfolio of chemical evaluation products to meet specific decision needs.
This page provides a list of final IRIS assessments in alphabetical order by chemical name.
Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook.To access assessment …
CASRN | DTXSID4023886 IRIS Summary (PDF) (29 pp, 186 K) Workshop & meeting details from the development of the draft IRIS Assessment for …
This IRIS assessment for Maneb consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
Using U.S. EPA's revised draft 1999 Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), diesel exhaust (DE) is likely to be carcinogenic to humans by inhalation from environmental exposures. This may be a synopsis of the full weight-of-evidence narrative.
Basis: Based on inadequate human and animal data. Epidemiologic studies failed to show a correlation between exposure to elemental mercury vapor and carcinogenicity; the findings in these studies were confounded by possible or known concurrent exposures to other chemicals, including human carcinogens, as well as lifestyle factors (e.g., smoking).
CASRN 1 | DTXSID9020794. Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS …
IRIS Summary (PDF) (8 pp, 93 K) Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the …
Basis: Inadequate evidence for oncogenicity in animals. Glyphosate was originally classified as C, possible human carcinogen, on the basis of increased incidence of renal tumors in mice.
Under EPA's Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), Cr(VI) is "likely to be carcinogenic" via oral exposure based on sufficiently supported [laboratory] animal studies relevant to …
This IRIS assessment for Benzaldehyde consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Developmental: 5 x 10 -4 (Chronic) Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and rats
19 rowsThe Integrated Risk Information System (IRIS) is a data base that contains EPA scientific consensus positions on potential human health effects from …
This IRIS assessment for Cyanide, free consists of hazard identification and dose-response assessment data and provides support for EPA risk management decisions.
System RfD (mg/kg-day) Basis PoD Composite UF Confidence; Hepatic: 5 x 10 -2: Hepatic lesions: NOAEL : 5.0 x 10 1 mg/kg-day
Additional EPA toxicity information may be available by visiting the following sites: Human Health Benchmarks for Pesticides (HHBP).This database provides human health benchmarks for pesticides that may be present in drinking water.
Note: The RfD for 1,2,3-TMB is based on data for 1,2,4-TMB and route-to-route extrapolation.See Section 2.2.3 of the Toxicological Review for additional details.
Basis: In animals, local sarcomas have been induced after implantation of foils and discs of silver. However, the interpretation of these findings has been questioned due to the phenomenon of solid-state carcinogenesis in which even insoluble solids such as plastic have been shown to result in local fibrosarcomas.
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